JI-Kan Ryu

Education and Training

Date                       Institution / Location       Degree                   Field

02/1993                 Yonsei University, Korea   M.D                        Medicine

02/2004                 Inha University, Korea        Ph.D.                      Medicine

Employment and Position

Period                   Affiliation                                                                             Position

2002-present        College of Medicine, Inha University                                             Professor

2025-present        Korean Society for Sexual Medicine and Andrology   resident

2022-2025            Translational Research Center, Inha University Hospital            Director

Important Publications (Up to 5)

MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2. Exp Mol Med. 2025;57(1):104-117.

Fibroblasts enable penile erection. Science. 2024;383(6683):588-589. 

Crystal structure of LRG1 and the functional significance of LRG1’s glycan for LPHN2 activation Experimental & Molecular Medicine, 2023;55(5):1013-1022. 

Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function. Experimental & Molecular Medicine, 2022;54(5):626-638.

Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse. Proc Natl Acad Sci U S A. 2014;111(26):E2731-40.

Research Interest

Peripheral vascular disease/Peripheral neuropathy

Angiogenesis/Neural regeneration/Tissue fibrosis